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Sylwia Chelstowska

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Open access Jul 2026

Validated high throughput microneutralization assay for anti-AAV2 neutralizing antibodies (NAbs) in clinical trials in support of gene therapy 2247247

Recombinant adeno-associated (AAV) viral vectors are being widely used in gene therapy. One of the challenges for AAV-based therapy is the presence of pre-existing neutralizing antibodies (NAbs) that humans develop against AAV throughout life. These NAbs inhibit the binding of viral vector to the cells resulting...

A. Gorbachev, Miriam Frangini, Sylwia Chelstowska et al. · 0 citations

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