Sylvia J. Gasparini

Extensive monolayer formation after transplantation depends on an RPE subpopulation derived from human iPSCs

Summary Loss of retinal pigment epithelium (RPE) in the eye leads to photoreceptor dysfunction, death, and eventually, vision loss. Cell replacement strategies using RPE cells derived in vitro from pluripotent stem cells are currently evaluated as a potential therapeutic strategy. Generation of polarized monolayers rep...