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Author

Syed Haider

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Open access Sep 2026

PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer

Most Triple Negative Breast Cancers (TNBCs) are p53 mutant high-grade invasive ductal carcinomas with a basal-like transcriptional programme. A large proportion of TNBCs also have mutation signatures indicating defective homologous recombination (HR) DNA repair. While HR deficiency is mutagenic and oncogenic, it can al...

V. Amodeo, D. Weekes, Nicolae Balan et al. · 0 citations
Open access Sep 2026

Massively parallel functional profiling prioritises breast cancer risk variants and implicates CCDC88C in ER-positive breast cancer.

This work identified 709 variants mapping to 140 risk regions, that are associated with significant variation between REF and ALT alleles, that may influence breast cancer risk through expression of CCDC88C, which in turn could impact prognosis.

Kate Mackie, H. Kemp, A. Gunnell et al. · 0 citations

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