In Silico Screening and Validation of Natural Components as Novel P-glycoprotein Inhibitors to Enhance the Bioavailability of Cancer Drugs
Background: Multidrug resistance in cancer arises when p-glycoprotein is overexpressed, actively expelling chemotherapeutic agents from cancer cells, thereby lowering their intracellular concentrations and diminishing the effectiveness of conventional therapies. However, in silico and docking-based screening of natural...