Author

Sven Brüschweiler

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Open access Jul 2026

A Comprehensive 19F NMR Framework for Fragment-Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR.

The design and validation of a non-proprietary 19 F NMR screening library (OpenFL600) capable of probing diverse binding pockets, as demonstrated for RNA, G protein-coupled receptors, kinases, protein-protein interactions, and proteases is presented.

Simon H. Rüdisser, Gabriela R. Stadler, G. Padroni et al. · Angewandte Chemie · 0 citations