Fmoc/Oxazolidinone Orthogonality Enables the Total Synthesis of a Structurally Complex, Conjugation-Ready Trisaccharide Repeating Unit of Vibrio cholerae O100.
Herein, we report the total synthesis of a structurally complex trisaccharide repeating unit of Vibrio cholerae O100 via an orthogonal amine protecting group strategy. This approach involves the preparation of rare amino sugars, and regioselective glycosylation followed by post-glycosylation amidation using dHh (3,5-di...