Chronic exposure to ultraviolet (UV) radiation is the dominant environmental driver of premature skin ageing. UVB is absorbed mainly in the epidermis, whereas the more abundant UVA reaches the dermis; together they generate reactive oxygen species, activate MAPK, AP-1 and NF-κB signalling, depress Nrf2-dependent defenc...
Sushil Kumar, Vishal Kumar, S. Kushwaha et al.· Iconic research and engineer...· 0 citations
The emergence of antimicrobial resistance has increased the need for novel
bioactive molecules with improved efficacy and sustainable synthetic approaches. This study aimed
to develop vanillin-derived chalcone–Schiff base hybrids using a green chemistry-assisted synthetic
strategy and to evaluate their antimicrobia...
J. Sharma, Sushil Kumar, Muazzim Ali et al.· Current Organocatalysis· 0 citations
Chalcone-arylpiperazine hybrids represent a potentially valuable scaffold for antianxiety drug development, however, the mechanistic insights derived from computational studies require robust in vivo and mechanistic validation to confirm therapeutic relevance.
Sushil Kumar, Malavika Puthanveetil Sureshbabu, N. Sati et al.· Central Nervous System Agent...· 0 citations
This review summarizes recent synthetic strategies, pharmacological activities, structure-activity relationships, and biosynthetic and mechanistic insights highlighting the significance of oxazole motifs in modern drug discovery.
J. Sharma, Sushil Kumar· Mini-Reviews in Medical Chem...· 0 citations
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