Sep 2026
S1P mimics phosphorylation to mediate PDK1-independent activation of aPKC with an opposing downstream effect.
Atypical protein kinase C (aPKC) isozymes play opposing roles in oncogenic and tumor-suppressive signaling pathways. These kinases are activated by phosphoinositide-dependent kinase 1 (PDK1) as well as by direct binding of the lipid second messenger sphingosine 1-phosphate (S1P). Here, we found that S1P and PDK1 provid...
Taketoshi Kajimoto, Ambuj Srivastava, Jing Zhang et al.
· Science Signaling · 0 citations