Amiodarone-induced disruption of thyroid hormone signaling derails patterning and epithelial-mesenchymal dynamics during chick hindlimb development.
It is suggested that intact TH signaling might be essential for coordinating patterning cues, epithelial-mesenchymal balance, cell survival, and extracellular matrix maturation during chick hindlimb development, and that amiodarone exposure is associated with disruption of these integrated developmental programs, which...