Author

Supun Ranaweera

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Open access Sep 2026

Mechano-Chemical Coordination of Nanoparticle-Based Artificial Antigen-Presenting Cells Synergistically Tunes T Cell Activation and Expansion Phenotypes.

Particle-based artificial antigen-presenting cells (aAPCs) are widely used for ex vivo T cell activation, but rigid, high-avidity stimulation can promote differentiation and exhaustion, reducing therapeutic efficacy. Because T cells sense mechanical forces through the T cell receptor, we engineered nanocapsule aAPCs wi...

Zi-Chao Guo, Fei Hou, Ya-Li Zhang et al. · Small · 0 citations

Open access Aug 2026

Mesenchymal stem cell-derived liver-on-a-chip reconstitutes human liver structure and function.

An in vitro model of human liver with functional integrity would advance liver research and enable personalized therapeutics. A microfluidic liver-on-a-chip can generate a functional hepatobiliary network using human liver cells and recapitulate blood circulation and bile excretion. However, many current microfluidic l...

Anastasia Brooks, Haotian Yang, D. Barkauskas et al. · Cell Reports Methods · 0 citations