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#protein folding Sep 2026

Automated Flow Synthesis of Nature-Derived, Engineered, and De Novo -Designed Functional Luciferases

Abstract Luciferases are widely used bioluminescent reporters, yet access to these enzymes has historically relied on recombinant expression. Using automated fast-flow peptide synthesis (AFPS), we synthesized Gaussia luciferase (GLuc, 18.1 kDa, 168 amino acids), picALuc (13 kDa, 120 amino acids), and LuxSit-i (13.8 kDa...

David Sarabia-Castillo, Amanda E. Cowfer Chavez, Sunit Pal et al. · 0 citations

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