Open access
Aug 2026
PreFold-dG: estimating binding affinity of protein–protein interaction from intermediate representations of protein folding model
PreFold-dG is presented, a model that estimates binding affinities of protein complexes utilizing intermediate embeddings from Boltz-2, an open-source foundation model for protein structure prediction and achieved state-of-the-art performance on well-established binding affinity prediction benchmarks and demonstrated robustness on independent test sets.
Sungjoon Park, Soorin Yim, Dongyun Kim et al.
· Bioinformatics · 0 citations