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Sun-Liang Cui

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Discovery of Novel Nonsteroidal SGRMs of Sulfonamide-2-Oxo-Tetrahydroquinoline Derivatives by Carbonyl Migration.

D8, which contained 2-oxo-tetrahydroquinoline by carbonyl migration form B53, manifests an excellent SGRM with remarkable transrepression potency and optimized binding mode within the GR LBD, underscoring its therapeutic potential and validating the design strategy.

Xiaodong Bao, Yuxin Zhou, Zhaoxu Yang et al. · 1 citation

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