Sumudu Leelananda

Massively Parallel, Single-Molecule Assessment of Synthetic Fidelity and Drug-Like Properties in a DNA-Encoded Library.

DNA-encoded libraries (DELs) are powerful drug discovery tools, enabling rapid hit generation against immobilized protein targets. However, translating these hits is often hampered by synthetic inefficiency and, for libraries of "beyond-Rule-of-5" compounds such as macrocyclic peptides, by enrichment of poorly cell-per...