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Author

Suman Pal

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Aug 2026

Enhancing the Membrane Destabilization Capacity of DNA-Surfactant Conjugates for Improved Cytosolic Delivery of Nucleic Acids.

This work describes a chemical approach to deliver multi-tailed DNA-surfactant conjugates into cells using nucleic acid nanocapsules (NANs) and shows that these multi-tailed DSCs improve DNAzyme-mediated gene silencing and enhance mRNA delivery in vitro, owing to their enhanced membrane disruption capabilities reflected in both cell studies and molecular dynamics simulations.

Joseph Gorecki, Ina F de la Fuente, Patrick M. Corrigan et al. · 0 citations

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