Sully F. Chen

An interpretable peptide–HLA model emergently learns binding energetics and structure

The range of peptides a human leukocyte antigen (HLA) binds and displays modulates immune response and therefore underpins vaccine design, neoantigen discovery, autoimmunity, transplantation, and hypersensitivity reactions. Modern predictors of peptide–HLA (pMHC) binding and presentation are remarkably accurate, but th...