A genome-wide CRISPR knockout screen identified host genes essential for Brucella invasion and intracellular survival
ABSTRACT For Brucella spp., the ability to invade and survive within host macrophages is essential for causing chronic infections in their mammalian hosts. In this study, a genome-wide CRISPR knockout screen was performed for the first time in human THP-1 macrophages to identify host genes mediating resistance to Bruce...