Open access
Aug 2026
Enhancing Enzyme Activity Via Noncovalent Association with DNA-Functionalized Nanoparticles
Enhancing enzyme performance without protein engineering remains a central challenge in biocatalysis. Here, we report the unusual discovery that nanoparticles densely functionalized with DNA, commonly known as spherical nucleic acids (SNAs), can bind enzymes without chemical conjugation, affinity tags, or engineered re...
Seungheon Lee, Atri Bhattacharya, Regan Kuttler et al.
· JACS Au · 0 citations