Open access
Sep 2026
Multimodal profiling establishes ovarian fibrosis as a measurable and targetable hallmark of human reproductive aging
Ovarian aging underpins infertility, systemic morbidity, and mortality in women. Stromal fibrosis is implicated in ovarian aging but has not been defined in the human ovary in situ. We integrated shear wave elastography (SWE), extracellular matrix (ECM) neoepitope fingerprinting, and single-cell RNA sequencing of folli...
L. Hughes, E. Zaniker-Gomez, P. Devrukhkar et al.
· Research Square · 0 citations