Su-Lin Zhang

Laminarin suppresses PD-L1 translation by targeting YTHDF1 to exert antitumor immunity in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is characterized by low response rates and rapid acquired resistance to current immunotherapies, highlighting an urgent unmet clinical need for novel therapeutic strategies. Herein, we demonstrated that laminarin, a biocompatible β-1,3-glucan extracted from brown algae, exerts signi...

Targeting the FOXP3—T-bet interaction to restore Treg stability in IFN-γ—driven autoimmunity 2254306

Regulatory T cells (Tregs) maintain immune homeostasis through FOXP3-centered transcriptional complexes that tightly control lineage stability and suppressive function. However, how specific FOXP3 mutations disturb this complex and drive pathogenic Treg reprogramming in IPEX syndrome remains unclear. We identifie...

Targeting the FOXP3–T-bet interaction to restore Treg stability in IFN-γ–driven autoimmunity

Development of potent and selective ENPP1 inhibitors based on imidazo[1,2-a]pyrazine and pyrazine scaffolds for cancer immunotherapy.

Results establish 15 and 17 as promising ENPP1 inhibitors with favorable safety profiles, supporting their potential in combination cancer immunotherapy.

Mapping Non-Homologous Pocket Compatibilities to Identify Hidden Drug-Target Relationships: A Pocket Hopping Framework.

Predicting small molecule-protein interactions across nonhomologous proteins remains challenging because shared ligand recognition is often not evident from sequence, fold, or pocket similarity. Here, we introduce pocket hopping, a machine-learning framework that learns residue-level interaction patterns from coligand...