Distinct molecular profiles of indeterminate and malignant thyroid nodules in patients under 21 years of age
The RET/NTRK/ALK-positive <21-year group demonstrated enrichment of angiogenesis and EMT pathways, higher ERK/EMT/FMT scores, and lower BRS/TDS vs genotyped-matched adults, providing mechanistic insight into the more invasive phenotype in pediatric and young adult TNs.