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Author

Steven D. Leach

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Open access Jul 2026

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.

To define mutation-specific lineage reversion and tumor initiation, Ptf1a-tdTomato mice and multiple KRAS mutants are implemented across several genetic, pharmacologic, and inflammatory perturbations in vivo to deciphering mutation-specific oncogenic trajectories and directing the implementation of KRAS-directed therap...

A. Grimont, David Falvo, W. Sisso et al. · 1 citation
Open access Aug 2026

Evolutionarily conserved epigenetic regulation of transcriptional cell states during vertebrate pancreatic tumorigenesis.

These findings suggest a highly conserved role for HDAC9 and class IIA HDACs in vertebrate pancreatic tumorigenesis and may lead to new strategies for reactivating (normal acinar/epithelial) differentiation programs to intercept and treat PDAC.

Somer Matar, Sandra Blázquez-Araguás, Andrea Diéguez-Docampo et al. · 1 citation

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