Author

Steven D. Bruner

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#protein folding Open access Oct 2026

Structure and Function of Archaeal SRP54 Protein Mutants Associated with Human Severe Congenital Neutropenia

SRP54, a key component of the signal recognition particle, is a highly conserved enzyme both structurally and functionally. The protein plays a vital role in cellular protein translocation by interacting with the translating ribosome and a membrane receptor, thereby aiding protein folding and trafficking. Recent stud...

Ming Yang, Andrew D. Brim, Lawton F. Long et al. · ACS Omega · 0 citations

Open access Sep 2026

Biosynthetic origin of anticancer dolastatin 15 reveals a noncanonical NRPS architecture enabling 2-keto acid activation.

Elucidating the biological origins and biosynthetic pathways of marine natural products remains a major challenge, particularly for compounds derived from microbial consortia. Here, we identify the marine cyanobacterial genus Dapis as the source of the potent anticancer natural product dolastatin 15 using genome-resolv...

Man-Yun Chen, Jie Liu, Hsin-Ying Tsai et al. · Proceedings of the National... · 0 citations