Open access
Aug 2026
The glycine N-methyltransferase amino-terminus regulates folate-dependent feedback inhibition and S-adenosylmethionine homeostasis
Maintenance of S-adenosylmethionine (SAM) homeostasis is essential for methylation of biomolecules, nucleotide and polyamine synthesis, and redox balance. While all methyltransferases consume SAM, only a subset of highly tissue-specific methyltransferases regulate methylation potential. Among them, glycine N-methyltran...
Isaac Kraz, Oi-Wei Mak, Subray Hegde et al.
· Journal of Biological Chemis... · 0 citations