Author

Stephen D. Fried

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#protein folding Open access Sep 2026

Catechol-O-methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia

It is demonstrated that loss of membrane-bound catechol-O-methyltransferase (MB-COMT), a key degrader of DA in the brain, disrupts cellular metal handling and redox-regulatory pathways and triggers widespread protein misfolding in schizophrenia and Parkinson’s disease.

S. Tripathi, Suwarna Chakraborty, Neil B. Wood et al. · Proceedings of the National... · 0 citations

Aug 2026

Global Incorporation of a Photo-Cross-Linking Amino Acid to Probe the Protein Interactome under Physiological Conditions.

Proteome-wide incorporation of DizPK, a diazirine-containing lysine analog with a dedicated MS-cleavable urea functionality, is demonstrated via stochastic orthogonal recoding of translation and subsequent identification of photo-cross-linked peptides to map protein-protein interactions under physiological conditions.

Piyoosh Sharma, Divya Yadav, Anneliese M. Faustino et al. · Journal of Proteome Research · 0 citations

#protein folding Sep 2026

Improving Yield and Assessing Quality of Secreted Proteins Over-Expressed in Pichia Pastoris with Chaperones and Structural Mass Spectrometry.

It is demonstrated that maximizing recombinant protein production requires optimization of both yield and structural quality and establish complementary strategies for improving secreted protein expression in Pichia.

Xin-Zhe Ren, E-Ming Rau, Lauren Coutu et al. · ACS Synthetic Biology · 0 citations