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Author

Stephen B. Baylin

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Open access Sep 2026

Cryo-EM structures of autoinhibited and RNA-activated ZNFX1 helicase

Cryo-electron microscopy and biochemical analyses support a regulatory mechanism in which autoinhibited ZNFX1 exists as monomers or concentration-dependent higher-order oligomers, whereas RNA binding promotes structural remodeling and helicase activation.

Qing He, Feng Wang, F. Rassool et al. · 0 citations
Open access Jul 2026

STING agonists in combination with epigenetic drugs potentiate ZNFX1-driven inflammatory necroptosis in TP53 -mutated AML

TP53-mutated AML potentiates effects of novel next-generation STING agonist C92, with unique allosteric and non-cyclic dinucleotide (non-CD) mechanism of action, inducing increased STING activation and cytokine release STING agonists and DNMTis, synergistically increase STING activation with marked transcriptome-wide i...

K. Tripathi, Lora Stojanovic, Zahra Gohari et al. · 0 citations

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