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Author

Stephanie Ma

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Open access Sep 2026

MAP2-mediated integrin dysregulation reprograms cancer cell plasticity in hepatocellular carcinoma

Targeting tumor cell plasticity is central to overcome drug resistance and metastasis. Through lineage-tracing and lineage-ablation studies, our team has previously shown hepatocellular carcinoma (HCC) cells marked by CD133 to represent a functional subset displaying dedifferentiated status with stemness traits, yet th...

U. Lou, Tin-Lok Wong, I. B. Huang et al. · 0 citations
Open access Jul 2026

Tumor-derived annexin A1 drives lenvatinib resistance by regulating SOX2/STAT3/S100A6 feedback loop and M2 macrophage polarization in hepatocellular carcinoma

The critical role of HCC-derived ANXA1 regulates lenvatinib resistance both intrinsically and extrinsically is demonstrated, and Targeting the SOX2/ANXA1/STAT3/S100A6 positive loop may provide a novel therapeutic strategy for HCC treatment.

Catherine Yu Jia Gu, C. Leung, R. Leung et al. · 0 citations

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