Preprint
Aug 2026
A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization
SABLE (Synthetically-accessible Agentic Bayesian Ligand Exploration), an open-source framework that employs natural-language orchestration to guide chemical structure optimization, is presented.
Kelvin Idanwekhai, Enes Kelestemur, Benjamin Strickland et al.
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