Author

Stefano Vanni

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Open access Aug 2026

Differential lipid selectivity of StARD phospholipid transporters revealed by native MS

Intracellular lipid transport in eukaryotes is largely mediated by lipid transfer proteins (LTPs). Transport kinetics differ markedly among lipid species, implying selective lipid recognition by the involved proteins. Here, we characterize endogenous ligands of the human phospholipid transporters STARD2, STARD7, and ST...

Carla Kirschbaum, Sophie A. S. Lawrence, Jack L. Bennett et al. · Nature Communications · 0 citations

Open access Aug 2026

The dystonia-associated Torsin1A sustains CLCC1 function in membrane fusion of the nuclear envelope for NPC biogenesis.

The conserved membrane protein Chloride Channel CLIC-like protein 1 (CLCC1) is identified as a Torsin1A interaction partner whose absence phenocopies membrane fusion defects caused by Torsin deletion inform a model of nuclear envelope membrane fusion and imply that modulating CLCC1 expression is a promising therapeutic...

D. Maslennikova, Harry J. M. Baird, Xinyue Ding et al. · Molecules and Cells · 3 citations · ⚡1

Open access Jul 2026

Capabilities, specificity gaps and training-data dependence of AlphaFold3 across diverse application areas

It is found that, while AF3 can perform well in favourable settings, this performance is uneven across applications and its predictions and use of confidence metrics will depend strongly on the specific application area and must be interpreted with respect to training-set overlap.

O. Follonier, Yan Liu, Pablo Campomanes et al. · bioRxiv · 1 citation