Open access
Aug 2026
The structural basis for LRRK2's activation and autoinhibition.
A unified framework for understanding LRRK2 regulation with broad therapeutic implications is provided, showing that the ROC GTPase governs switching between autoinhibited and active states: GTP binding promotes activation, whereas GDP binding enforces autoinhibition.
Amalia Villagran Suarez, Kathryn S. Hatch, Tatyana Bodrug et al.
· Cell · 0 citations