Open access
Aug 2026
Bioinformatic Characterization of Regulated IRE1α-Dependent Decay (RIDD) in Heart Failure
Inositol-requiring enzyme 1α (IRE1α) is a canonical signaling factor in the unfolded protein response (UPR). In addition to this essential role (which prevents the accumulation of misfolded proteins in the endoplasmic reticulum), the endoribonuclease activity of IRE1α targets multiple mRNAs for degradation through a pr...
Nisha Bhattarai, Angelina Kendi, M. Stoner et al.
· bioRxiv · 0 citations