Author

Sruthi Sudhakar

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Open access Sep 2026

Inositol Hexakisphosphate Promotes Open Pore State in HIV Capsid Protein Lattice by Reconfiguring Subunit Contacts

IP6 is established as a proviral regulator that couples nanoscale pore dynamics, intersubunit contact reconfiguration, and mechanical resilience of the HIV-1 capsid, providing a unified mechanistic framework for its role in viral replication.

Y. Knelissen, Judith Escrig, Amanda C. Macke et al. · ACS Nano · 0 citations

Open access Aug 2026

CRISPR RNA architecture steers Cas9 catalysis and fidelity via a guide repeat clasp motif

A previously unknown mechanism that steers Cas9 catalysis is uncovered and the potential to improve Cas9 fidelity by modulating guide repeat interactions is demonstrated.

Ramadevi Chilamkurthy, Sruthi Sudhakar, Adrian A. Pater et al. · Nucleic Acids Research · 0 citations