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Srinivas Thadkapally

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Aug 2026

Thioester Bond Formation Catalyzed by CalO4: A β-Ketoacyl-ACP Synthase III-like Acyltransferase in Calicheamicin Biosynthesis.

A KAS III family enzyme, CalO4, is described that catalyzes C-S bond formation during the biosynthesis of the potent antitumor agent calicheamicin and provides a potential biocatalyst for hindered C-S bond formation and a target for engineering novel calicheamicin-like or other bioactive compounds.

Fang Pang, Yu-Ju Peng, Srinivas Thadkapally et al. · 0 citations

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