Author

Srinivas Gopala

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Sep 2026

Coenzyme Q10 supplementation restores mitochondrial respiration in patients with primary CoQ10 deficiency caused by novel COQ2 and COQ4 variants

Functional evidence is provided that defective mitochondrial function in these conditions is, at least in part, reversible with targeted CoQ10 therapy, underscoring the importance of early genetic diagnosis and timely initiation of CoQ10 supplementation.

Achanya S. Jayan, Priya Nataraj, Arun Kumar Gangadharan et al. · Metabolic brain disease · 0 citations

Sep 2026

Cofilin 1 Is an Extracellular Vesicle-Associated Plasma Biomarker of Parkinson's Disease in Humans.

OBJECTIVE Parkinson's disease (PD) lacks reliable, minimally invasive biomarkers for diagnosis. This study aimed to identify and validate PD-specific plasma extracellular vesicle (EV)-associated proteins. METHODS Plasma EVs were isolated by ultracentrifugation and characterized. Proteomic profiling of total plasma EV...

Deepthy Chandran, Unnati Agrawal, D. Damayanthi et al. · Annals of Neurology · 0 citations

Aug 2026

Identification and validation of Parkinson’s disease relevant microRNAs in plasma extracellular vesicles

The EV miRNAs, specifically, hsa-let-7e-5p, hsa-miR-19b-3p, hsa-miR-24-3p, and hsa-miR-331-5p are promising candidates for PD diagnosis as they are associated with regulatory pathways involved in PD pathogenesis.

Deepthy Chandran, Syam Krishnan, Srinivas Gopala et al. · Neurological Sciences · 0 citations