Sreekanth Madhusoodhanan Nair

Fast Submillimeter Whole‐Brain T2*‐Weighted Imaging Using 3D‐EPI With CAIPIRINHA and Deep‐Learning Denoising at 3T

Recent updates to the diagnostic criteria of multiple sclerosis (MS) require whole‐brain T2*‐weighted (T2*w) imaging with submillimeter resolution to detect novel diagnostic biomarkers such as the central vein sign. However, to achieve the needed submillimeter spatial resolution, conventional T2*w 3D gradient‐echo scans sequences are limited by prohibitively long scan times for clinical use. Here, we evaluated a different approach based on a segmented 3D echo planar imaging (3D‐EPI) sequence, accelerated with 2D Controlled Aliasing in Parallel Imaging Results in Higher Acceleration (CAIPIRINHA) undersampling and denoised with a deep learning‐based network.