Spencer H. Thompson

XRCC1 Enables the Efficient Local Search for DNA Damage by DNA Polymerase Beta

Oxidative DNA damage is a common threat to genomic integrity, arising from endogenous metabolic processes and environmental exposures. If unrepaired, such oxidative DNA damage promotes mutagenesis and genomic instability. Cells counter this through base excision repair (BER), a multi-step pathway requiring the coordina...