Speeckaert Reinhart

Systemic pruritus as a neuroimmune disorder: Mechanistic insights and target-driven therapy.

Chronic pruritus in the absence of primary skin disease is a frequent, disabling and diagnostically complex symptom that may precede the clinical manifestation of systemic disorders. Renal, hepatobiliary, endocrine, metabolic, hematologic, malignant, neuropathic and drug-induced conditions account for approximately 10%...