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Author

Sougata Guha

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Open access Sep 2026

Scaling of structural variability of ecDNA polymer condensates with copy number boosts and stabilises oncogene regulatory contacts

A minimal polymer physics model of MYC-harbouring COLO320-DM ecDNAs is developed, revealing universal polymer physics principles underlying ecDNA condensate organization, offering a mechanistic basis for selective oncogene amplification and potential advantages in cancer progression.

Mattia Conte, Sumanta Kundu, Sougata Guha et al. · 0 citations

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