Open access
Sep 2026
Scaling of structural variability of ecDNA polymer condensates with copy number boosts and stabilises oncogene regulatory contacts
A minimal polymer physics model of MYC-harbouring COLO320-DM ecDNAs is developed, revealing universal polymer physics principles underlying ecDNA condensate organization, offering a mechanistic basis for selective oncogene amplification and potential advantages in cancer progression.
Mattia Conte, Sumanta Kundu, Sougata Guha et al.
· bioRxiv · 0 citations