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Author

Sota Yagi

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Open access Jul 2026

Prebiotic cationic amino acids support formation of an ancient protein fold

Crystallographic analysis revealed that both this peptide and its Dab-substituted derivative adopted the double-Z β-barrel (DZBB) fold, a likely evolutionary intermediate between extant β-barrel folds, which might have supported the foldability of primitive proteins before the incorporation of lysine and arginine into the genetic code.

Sota Yagi, Aditya K. Padhi, Khushboo Bhagat et al. · 0 citations

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