Author

Sophia Vincoff

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Open access Aug 2026

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo

Aberrant activation of Wnt signaling results in unregulated accumulation of cytosolic β-catenin, which subsequently enters the nucleus and promotes transcription of genes that contribute to cellular proliferation and malignancy. Here, we sought to eliminate pathogenic β-catenin from the cytosol using designer ubiquibod...

Tianzheng Ye, A. Alamgir, C. Robertus et al. · Science Advances · 0 citations

Open access Aug 2026

A Mammalian High-Throughput Screen for AI-Designed Peptide-Guided Protein Degraders

Targeted protein degradation (TPD) offers a route to eliminate disease-driving proteins that remain inaccessible to conventional inhibitors. However, degrader discovery remains low-throughput, labor-intensive, and dependent on randomized libraries or non-human display systems, limiting functional selection in mammalian...

Lin Zhao, Anuoluwapo A. Mattix, Aastha Pal et al. · bioRxiv · 0 citations

Open access Jul 2026

PeptiVerse: A unified platform for therapeutic peptide property prediction

PeptiVerse is a unified platform that leverages large foundation models to predict diverse peptide developability properties from both amino acid sequences and SMILES representations, enabling accessible, scalable analysis for peptide drug design.

Yinuo Zhang, Sophia Tang, Tong Chen et al. · Nature Communications · 5 citations · ⚡1