Sophia Rha

Abstract B010: ELUCIDATING DNA DAMAGE REPAIR SIGNALING AND THERAPEUTIC VULNERABILITIES ACTIVATED BY TRANSPOSASE-DERIVED PGBD5

One hallmark of pediatric tumors is their low mutational burden, which contrasts with adult tumors, where cancer-causing mutations often accumulate over decades of DNA replication and environmental exposure. This raises the question of how such mutations arise in young patients. We have proposed that developmental mu...