Author

Soojin V. Yi

3 papers indexed here

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Open access Sep 2026

Transcriptome of fetal cortex of tree shrew underlying the emergence of outer subventricular zone

A defining feature of primates is the expansion and increased complexity of the cerebral cortex, processes that are largely associated with evolutionary adaptations of the neural progenitor-enriched outer subventricular zone (OSVZ). Yet, the genetic mechanisms underlying the emergence of the primate OSVZ remain unknown...

Ting Hu, Yang-Xuan Wen, Yu-Lian Tan et al. · Communications Biology · 0 citations

#protein folding Open access Sep 2026

CCNB1IP1 regulatory evolution underlies gradual increases in cortical size and folding in primates.

The gradual expansion and folding of the cortex are key factors in human cognitive evolution, yet their molecular underpinnings remain not well understood. Here we identify cyclin B1 interacting protein 1 (CCNB1IP1) gene as a key regulator of human brain evolution using tree shrew as an outgroup. In primates, CCNB1IP1...

Ting Hu, Peng-Cheng Ma, Yi-Fan Kong et al. · Nature Genetics · 0 citations

Aug 2026

Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling.

A non-random nuclear "ribome," the genome-wide landscape of embedded rNMPs, enriched in GC-rich regions, regulatory elements, and telomeres, is revealed, revealing a connection between ribonucleotide processing and transcription-associated DNA topology in human cells.

Deepali L. Kundnani, Yeunsook Lee, Taehwan Yang et al. · Cell · 0 citations