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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Sonja C. Schriever

h-index 18 View on Semantic Scholar

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Open access Oct 2026

Temporal organization of leptin signaling reveals distinct regulatory roles for STAT3 and ETV6.

Leptin regulates energy homeostasis through activation of its long-form receptor (LepRb), primarily via JAK2-dependent phosphorylation of STAT3. However, the temporal organization of leptin-induced transcriptional responses and how parallel signaling pathways contribute to these dynamics remain incompletely understood....

Ekta Pathak, Miriam Bernecker, Noémi Mallet et al. · 0 citations
Aug 2026

Central Thyroid Hormone Deprivation Disrupts Cortical Cilia and Oligodendrocyte Lineage in an Allan–Herndon–Dudley Syndrome Mouse Model

These findings provide the first single-cell–level cortical map of AHDS brain pathology, revealing cilia defects, excitation–inhibition imbalance, differing pseudotime trajectories in glutamatergic neuronal populations and altered oligodendrocyte maturation, with actionable candidate genes such as Lama2, Litaf, and Dcc...

Anna Molenaar, Ekta Pathak, Miriam Bernecker et al. · 0 citations

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