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Song-Yi Xue

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Aug 2026

Unconventional Biocatalytic Strategies Orchestrate the Synthesis of the Nucleoside Analog Sinefungin.

In vitro and in vivo analyses support a recent finding that the defining carbon-carbon bond is formed not by a long-hypothesized PLP-dependent process, but by a vitamin B12-dependent radical SAM enzyme, and expand upon the current knowledge of radical-mediated C-C bond formation and PEARL enzyme catalysis.

Chi-Fang Lee, T. Zhou, Songyi Xue et al. · 0 citations

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