A Non-Metallic DNA Intercalator from Pyronine-Aloperine Conjugation Reverses Cisplatin Resistance in Ovarian Cancer
Cisplatin (DDP) resistance remains a key factor contributing to the high mortality rate among ovarian cancer patients. The Pt(II)−DNA covalent adduct is prone to removal through changes in gene expression in tumor cells, resulting in DDP resistance. To address this challenge, developing a non-metallic DNA intercalato...