Alzheimer's disease (AD) is a significant healthcare concern due to the complex interactions between amyloid-β accumulation, tau pathology, neuroinflammation, synaptic dysfunction, and progressive neuronal death. Stem-cell-based therapies have demonstrated potential to treat this complex condition through immunomodulat...
Abstract Exosome therapy is emerging as a promising neuroprotective strategy for Alzheimer's disease (AD). We evaluated and compared whether normal exosomes (NE) and modified exosomes (ME) derived from AD rat brain extract‐treated rat bone marrow mesenchymal stem cells possess the potential to protect SH‐SY5Y cells aga...
French bean (Phaseolus vulgaris L.) is an important legume vegetable crop; the integrated use of biochar with inorganic fertilisers may improve soil properties, nutrient availability and nutrient-use efficiency. Therefore, evaluating this approach is important for achieving sustainable and productive French bean cultiv...
A. Maurya, Anil Kumar Singh, Om Kumar et al.· International Journal of Pla...· 0 citations
High mobility group box 1 (HMGB1) is a crucial modulator of neuroinflammation in AD, according to new research, and a viable treatment approach for reducing neuroinflammation and associated pathologies with AD is to target HMGB1-mediated signalling networks.
Prashant Tyagi, Sneha Kumari, Prajjwal Sharma et al.· International Immunopharmaco...· 1 citation
This chapter highlights the role of targeting ligands, stimuli-responsive systems, and tumor microenvironment-specific strategies in enhancing therapeutic efficacy while minimizing adverse effects, emphasizing the potential of molecularly targeted nanomedicine to advance precision therapy and improve clinical outcomes.
Aman Kumar, Md Hidul Islam, Pranav Dhingra et al.· Advances in Protein Chemistr...· 0 citations
Overall, this review makes a case for integrative, pathway-based therapeutic models, and multiple approaches may facilitate for drug development, biomarker identification and patient management in Alzheimer's disease.
