This review comprehensively summarizes and critically analyzes advances reported from 2020 to 2026 in the design, synthesis, biological evaluation, and therapeutic potential of RIV-based hybrid molecules and scaffold modifications for AD treatment.
Nitin Kumar, V. Kushwaha, Gourav Singh et al.· Bioorganic & Medicinal Chemi...· 0 citations
Evidence highlights BZT as one of the most promising privileged scaffolds for integrating early diagnosis, disease monitoring, and disease-modifying intervention within a unified molecular framework for neurodegenerative disorders.
Nitin Kumar, Izhar Khan, Jyoti Singh et al.· RSC Medicinal Chemistry· 1 citation
Rather than presenting DPZ-based hybrids as established disease-modifying therapies, the available evidence supports their role as promising multifunctional lead compounds and valuable molecular platforms for the rational design of next-generation anti-Alzheimer agents.
Nitin Kumar, Izhar Khan, Jyoti Singh et al.· Bioorganic chemistry (Print)· 1 citation
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