Smrithika Subramani

Alternative splicing of synaptotagmin 7 regulates oligomerization and short-term synaptic plasticity.

Synaptic plasticity is crucial for learning and memory. The presynaptic calcium sensor synaptotagmin 7 (syt7) regulates aspects of short-term plasticity (STP), but the underlying mechanisms remain unclear. Here, we show that alternative splicing of the syt7 juxtamembrane linker acts as a molecular switch at both bioche...