Aug 2026
Structure- and deep learning-guided engineering of a size-minimized CRISPR/Cas.
UCRISPRa achieved selective activation of olfr544 among more than a thousand homologous olfactory receptor genes in skeletal muscle cells, leading to enhanced mitochondrial biogenesis and broad potential for precise gene regulation and functional studies of complex macromolecular systems.
Smith Le, Trung Thach
· The FEBS Journal · 0 citations