Oct 2026
Longitudinal single-cell transcriptional profiling identifies dynamic neurodegenerative mechanisms in Christianson Syndrome rat
The findings define the cellular trajectories of neurodegeneration in CS, and identify convergent endolysosomal, mitochondrial, and inflammatory mechanisms that support a broader role for endolysosomal dysfunction in Alzheimer’s disease pathogenesis.
Hasib A. Riaz, Smijin K. Soman, Jessica F. Devlin et al.
· bioRxiv · 0 citations